Sendara® Nutraceutical Helps Prevent Accelerated Aging Through Iron Chelation & Other Properties

At normal levels, iron can play an important role in the body in the areas of oxygen transport and storage, energy production, and healthy immune function. Too much iron, however, can result in iron-catalyzed free radical formation that often leads to negative health consequences such as neurodegenerative disease, poor cardiovascular health, and accelerated aging of the skin. To help reduce the effects of excess iron in the body, supplementation with proven iron chelators is recommended. Iron chelators such as botanical extracts, polyphenols, and Sendara® branded nutraceutical for women (marketed by NutraGenesis) are able to bind excess iron so that its adverse catalytic properties are retarded.

Excess Iron Leads to Greater Oxidative Stress in the Body

Although iron is generally considered beneficial to the body, if too much exists in a free, unbound state it can be damaging. To safeguard against this, the body possesses iron storage molecules such as ferritin and transferrin that reversibly bind iron until needed for later use. When iron levels exceed the body’s physiological requirements and storage capabilities, unbound iron can act as a catalyst in a chemical process known as the Fenton Reaction. The Fenton Reaction leads to the systemic formation of several types of free radicals and reactive oxygen species (ROS). The resulting oxidative stress can lead to degradation of vulnerable cells and tissues.

Unhealthy Iron Levels Can Result in Degeneration of the Body

As we age, the amount of iron in our bodies can build up to unhealthy levels which can contribute to cognitive decline as well as degenerative diseases of the brain, heart, and liver. Studies have found that the degree of iron-related dysfunction is associated both with age and gender. Older people and men tend to have greater levels of iron in their bodies and also have greater risk of developing these health problems. Research conducted at UCLA has shed light on the relationship between excess iron levels in the brain and the degree of neuro-degenerative decline occurring in subjects.

Lifetime Accumulation of Iron is Associated with Cognitive Decline and Neurodegenerative Disease

In a series of studies led by Dr. George Bartzokis at the Semel Institute for Neuroscience and Human Behavior at UCLA, researchers used MRI scans to measure the amount of iron in subjects’ brains. In particular, they examined iron accumulation in areas of the brain that are most affected by neurodegenerative diseases such as Parkinson’s and Alzheimer’s, including the basal ganglia. The researchers found higher levels of iron in the brains of people suffering from these diseases than in healthy individuals. Higher iron levels in the basal ganglia at an earlier age also was associated with early disease onset. In a second study involving older, healthy subjects, Dr. Bartzokis and his colleagues found that those with the highest levels of iron in their brains suffered more cognition dysfunction (including poor memory and information processing) than did subjects with lower iron levels.

Variation in Age-Related Degenerative Disease is Associated with the Body’s Iron Load

Researchers wondered if limiting lifetime exposure to iron might be a way to protect the body against iron-induced cognitive decline. This seemed plausible, especially since men, on average, possess higher levels of iron in their bodies throughout their lives compared to women and also tend to experience neurodegeneration at an earlier age than women. A major reason for this gender difference, scientists hypothesized, is due to the monthly loss of blood that accompanies menstruation in women. A recent landmark study led by another UCLA researcher, Dr. Todd Tishler, produced evidence supporting this hypothesis by using a novel experimental approach.

The UCLA team studied three groups of subjects: 1) postmenopausal women who had menstruated until menopause, 2) women of the same age who had undergone a hysterectomy prior to menopause, and 3) men of similar age. MRI scans were taken to determine the amount of iron in the brain of each subject. The researchers hypothesized that women who had undergone a hysterectomy would have more iron in their brains than women who had continued to lose iron through menstruation….and they were right. Monthly loss of blood through menstruation led to a reduction in the iron load of women who had not received a hysterectomy. Conversely, women who had received a hysterectomy possessed higher iron levels that matched those observed in the brains of men. The study authors concluded that reducing iron levels prevents iron from building up to unhealthy levels which may be why women experience greater protection against age-related degenerative disease.

Supplementation with Iron Chelators May Help Shield the Body from Age-Related Degeneration

While it may be difficult for some people to limit the amount of iron in their bodies as a way to reduce the risk of degenerative disease, supplementation with nutraceutical ingredients that possess iron chelation properties may help limit the harm caused by excess iron that already exists in the body. Iron chelators are substances that bind free iron after it has been released from the body’s storage proteins and prevent it from catalyzing free radical formation. NutraGenesis markets a branded nutraceutical ingredient called Sendara® that possesses proven iron chelation properties. Other examples of nutraceuticals with reported iron chelation properties include cranberry and pomegranate extracts, EGCG-rich green tea, quercetin (a flavonoid found in berries and other plants), curcumin (from turmeric), and milk thistle.

Sendara® Nutraceutical Ingredient is a Proven Iron Chelator

Sendara® is an advanced nutraceutical for women composed of multi-patented, GRAS affirmed, standardized extracts of two of nature’s most revered Ayurvedic botanicals. Patented Sendara®combines Sensoril®, a clinically proven extract of Ashwagandha (Withania somnifera) with Capros®, a clinically researched extract of the ultimate superfruit, Indian Gooseberry (Phyllanthus emblica). Each botanical is a renowned adaptogen replete with anti-aging, anti-stress, health restoring properties that increase the body’s resistance to negative physical, chemical, and biological factors for enhanced well-being.

Scientific analysis using the HORAC (Hydroxyl Radical Antioxidant Capacity) in vitro method has demonstrated that Sendara® possesses significant iron chelation properties. The HORAC method measures the ability of a nutraceutical to bind iron and prevent it from catalyzing free radical formation in the Fenton Reaction. The HORAC level for Sendara® was found to be substantially higher than other antioxidants such as Vitamin C and grape extract.

Sendara® Possesses Additional Anti-Aging Properties

In addition to its iron chelating properties, Sendara® possesses a novel “cascading” antioxidant property which provides protection from oxidative stress that lasts considerably longer than most conventional antioxidant ingredients do. Its glycowithanolide bioactives produce highly experiential benefits that help reduce stress and anxiety while enhancing mood. Scientific testing has also shown that Sendara® inhibits collagenase and hyaluronidase, two enzymes that can cause accelerated aging of the skin. These properties combined with the ability to chelate iron help support Sendara’s significant anti-aging benefits.

Sendara’s winning formulation represents a completely new approach to comprehensive women’s anti-aging and wellness with the scientific support and regulatory substantiation required to excel in today’s demanding marketplace. Based on Sendara’s multifunctional, anti-aging properties, it has been substantiated in the following structure/function claim areas: Anti-Aging, Mood/Emotional Outlook, Weight Management, Cardiovascular Health, Immune Support, Menopause, Mental Cognition, Energy, Blood Sugar Balance, and Antioxidant. These claims are in accordance with the requirements of the Dietary Supplement Health and Education Act of 1994 and have been submitted to the Food and Drug Administration accordingly.

Dr. Abedon received his M.S. and PhD in Plant Genetics from the University of Wisconsin-Madison and a B.S. in Biochemistry from the University of Massachusetts-Amherst. Dr. Abedon may be contacted through NutraGenesis at 802.257.5345, or bruce@nutragenesis.com.